Would love to see an option for "Remove Curse" for negative Karma characters perhaps via the Cleric and or Druid Books. Basically to give the player the choice of being evil Dread lord/lady while still maintaining the ability to remove curses. Seems rather silly considering it's the only spell in the paladin's playbook that actually takes karma into consideration. For those of us playing non dexxers Wither is simply the best spell for spawns and the like. I would absolutely LOVE to run the Dread Lady title and play an evil Necromancer, but to do so SEVERELY gimps my character in game. Shouldn't have to worry about karma just to be on an even playing field with others in my opinion.

Does the Purge spell from the Cleric spell book have any ties to karma? If not then this might be what you're looking for.

Looking at my Cleric spells it's just a guess, but I'm thinking positive karma is a factor...one spell, "Angel Faith", turns your character into what is described as a holy angel.  Other wording, such as, Sacrifice, Smite and Sacred seem to denote a positive karma.  Maybe you could borrow a book from a friend and try out "Repurgo", (the purge spell), after you curse & poison yourself--it should remove both at the same time, (pink flame graphic).  But if it relies on positive karma it may either do nothing or hurt you.  It's a great spell to have as it removes the toughest curses and poisons at once.